Proteomics versus Immunoassays

Pharmaceutical Advances and Proteomics Researches

Proteomics enables understanding the composition, structure, function and interactions of the entire protein complement of a cell, a tissue, or an organism under exactly defined conditions. Some factors such as stress or drug effects will change the protein pattern and cause the present or absence of a protein or gradual variation in abundances. Changes in the proteome provide a snapshot of the...

Multiplexed Immunoassays

Immunoassay has been widely used for quantification of proteins and small molecules in medical diagnostics, proteomics, drug discovery, and various biological research.1 ELISA (Enzyme-Linked ImmunoSorbant Assay) is the most commonly used immunoassay format.2 Traditional ELISA assays used in clinical settings are laborious and expensive and often consume large quantities of reagents and patient ...

Microfluidic Immunoassays

Graft-versus-host disease: proteomics comes of age.

In this issue of Blood, Paczesny and colleagues describe a set of 4 serum proteins that may help to confirm the diagnosis of acute GVHD and seem to be associated with worse survival independently of GVHD grade. Acute graft-versus-host disease (GVHD), the main complication of allogeneic hematopoietic cell transplantation, is mainly diagnosed clinically and can be confirmed by biopsy of 1 of the ...

Pharmaceutical Advances and Proteomics Researches

Proteomics enables understanding the composition, structure, function and interactions of the entire protein complement of a cell, a tissue, or an organism under exactly defined conditions. Some factors such as stress or drug effects will change the protein pattern and cause the present or absence of a protein or gradual variation in abundances. Changes in the proteome provide a snapshot of the...